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YONGWIMON LENBURY, RUJIRA OUNCHAROEN, NARDTIDA TUMRASVIN, Higher-dimensional separation principle for the analysis of relaxation oscillations in nonlinear systems: application to a model of HIV infection, Mathematical Medicine and Biology: A Journal of the IMA, Volume 17, Issue 3, 2000, Pages 243–261, https://doi.org/10.1093/imammb/17.3.243
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Abstract
In this paper, geometric and singular perturbation arguments are utilized to develop a separation condition for the identification of limit cycles in higher-dimensional ( n ≥ 4) dynamical systems characterized by highly diversified time responses, in which there exists an ( n - 3)-dimensional subsystem which quickly reaches a quasi-steady state. The condition, which has been used up to now to analyze relaxation oscillation in slow-fast systems, is extended to accommodate dynamical systems in which more state variables are involved in a special manner which still allows for the use of singular perturbation techniques. Application is then made to a model of human immunodeficiency virus infection in T helper (T H ) cell clones with limiting resting T H cell supply.