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Scott A. Stevens, Michelle Previte, William D. Lakin, Nimish J.Thakore, Paul L. Penar, Brandon Hamschin, Idiopathic intracranial hypertension and transverse sinus stenosis: a modelling study, Mathematical Medicine and Biology: A Journal of the IMA, Volume 24, Issue 1, March 2007, Pages 85–109, https://doi.org/10.1093/imammb/dql025
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Abstract
Idiopathic intracranial hypertension (IIH) is a syndrome of unknown etiology characterized by elevated intracranial pressure (ICP). Although a stenosis of the transverse sinus has been observed in many IIH patients, the role this feature plays in IIH is in dispute. In this paper, a lumped-parameter model is developed for the purpose of analytically investigating the elevated pressures associated with IIH and a collapsible transverse sinus. This analysis yields practical predictions regarding the degree of elevated ICPs and the effectiveness of various treatment methods. Results suggest that IIH may be caused by a sufficiently collapsible transverse sinus, but it is also possible that a stenosed sinus may persist following resolution of significant intracranial hypertension.