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GEORGE A. BURGHEN, JAMES R. GIVENS, ABBAS E. KITABCHI, Correlation of Hyperandrogenism with Hyperinsulinism in Polycystic Ovarian Disease, The Journal of Clinical Endocrinology & Metabolism, Volume 50, Issue 1, 1 January 1980, Pages 113–116, https://doi.org/10.1210/jcem-50-1-113
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Abstract
We evaluated basal plasma total immunoreactive insulin (insulin), androstenedione, and testosterone in 14 obesewomen: 8 with polycystic ovarian disease (PCOD) and 6 obese controls. All 3 hormones were significantly elevated (P < 0.02 to P < 0.001) in PCOD patients. A significant correlation amon basal levels of plasma insulin, androstenedione, and testosterone was demonstrated. The PCOD group had significantly higher levels of glucose at 1, 2, and 3 h, with similar significant increases in plasma insulin levels at 0, 2, and 3 h. A significant correlation was found between plasma insulin response areas and plasma testosterone (P < 0.001) in the control and PCOD patients. These studies demonstrate that hyperandrogenism correlates with hyperinsulinism.