Familial Autoimmune Thyroiditis: Maternal–Fetal Relationship and the Role of Generalized Autoimmunity

GOLDSMITH, R. E.; MCADAMS, A. J.; LARSEN, P. R.; MACKENZIE, M.; HESS, E. V.

doi:10.1210/jcem-37-2-265

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Familial Autoimmune Thyroiditis: Maternal–Fetal Relationship and the Role of Generalized Autoimmunity

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ABSTRACT

A family with autoimmune thyroid disease (Hashimoto's type) involving at least 3 members in 2 generations is described. In addition, abnormalities of serum immunoglobulins were identified in 2 of 3 generations studied. The possible pathogenetic role of at least one of these immunoglobulins is discussed. Congenital thyroid suppression (partially reversible) was present in all 6 offspring (third generation) of one member with autoimmune thyroiditis. The mechanism of this suppression is not apparent.

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Familial Autoimmune Thyroiditis: Maternal–Fetal Relationship and the Role of Generalized Autoimmunity

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Familial Autoimmune Thyroiditis: Maternal–Fetal Relationship and the Role of Generalized Autoimmunity

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