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KATRINA L. PARKER, PETER A. LEE, DEPOT LEUPROLTDE ACETATE FOR TREATMENT OF PRECOCIOUS PUBERTY, The Journal of Clinical Endocrinology & Metabolism, Volume 69, Issue 3, 1 September 1989, Pages 689–691, https://doi.org/10.1210/jcem-69-3-689
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Leuprolide acetate (D-Leu 6 des-Gly-NH210, Pro-ethylamide9) for depot suspension has been shown to be effective in suppressing gonadotropins in 6 patients. Serum LH and FSH response to exogenous LHRH was obliterated after 4 weeks and weekly urinary gonadotropin levels during depot therapy were suppressed. This form of this drug should be effective in the treatment of precocious puberty.
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Copyright © 1989 by The Endocrine Society
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