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Peter A. Beal, Peter B. Dervan, The influence of single base triplet changes on the stability of a Pur·Pur·Pyr triple helix determined by affinity cleaving, Nucleic Acids Research, Volume 20, Issue 11, 11 June 1992, Pages 2773–2776, https://doi.org/10.1093/nar/20.11.2773
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Abstract
The influence of sixteen base triplet changes at a single position within a pur·pur·pyr triple helix was examined by affinity cleaving. For the 15 base pair target site studied here, G·GC, A·AT and T·AT triplets stabilize a triple helix to a greater extent than the other 13 natural triplets (pH=7.4, 25°C). Weaker interactions were detected for the C·AT, A·GC and T·CG triplets. The absence of specific, highly stabilizing interactions between third strand bases and the CG or TA base pairs demonstrates a current sequence limitation to formation of this structure. Models for the two dimensional base triplet interactions for all possible 16 natural triplets are presented.
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