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Journal Article
ACCEPTED MANUSCRIPT
Roger J Packer
Neuro-Oncology, noae079, https://doi.org/10.1093/neuonc/noae079
Published: 17 April 2024
Journal Article
Corina Anastasaki and others
Neuro-Oncology, noae054, https://doi.org/10.1093/neuonc/noae054
Published: 12 April 2024
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Published: 12 April 2024
Figure 2. Midkine is sufficient for murine Nf1 -OPG growth. (A) Left, immunofluorescent staining reveals expression of CTL-GFP and Mdk-GFP AAV in the retinal ganglion cell layer (Brn3a + cells) of Nf1 OPG mice. Right, Mdk RNA expression is increased following AAV2- Mdk relative to AAV2-CTL injection
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Published: 12 April 2024
Figure 3. The germline Nf1 gene mutation dictates RGC excitability and midkine production. (A) Table summarizing the Nf1- mutant mouse strains analyzed. (B) Tumor proliferation (%Ki67 + cells) is increased in optic nerves from mice harboring OPGs relative to those without tumors. “No OPG,” 30 mice; “OPG,”
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Published: 12 April 2024
Figure 5. Lamotrigine treatment durably reduces Nf1 -OPG growth. (A, D) Schematic representation of mouse treatment and analysis timelines. (B, E) Left: Representative gross images of optic nerves and quantification show no change in LTR-treated Nf1 OPG optic nerve volumes relative to vehicle-treated (Veh
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Published: 12 April 2024
Figure 4. Selective inhibition of Nf1 -mutant RGC activity-dependent midkine production. (A, B) Nf1 -mutant RGC Mdk RNA expression is reduced following lamotrigine and rufinamide treatment, but not after the treatment with other antiepileptic drugs. A minimum of 3 independently generated replicates were u
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Published: 12 April 2024
Figure 1. Midkine is necessary for murine Nf1 -OPG growth. (A, B) Immunohistochemical staining (left) and RNA expression analysis (right) of Nf1 OPG ; Mdk −/− retinae reveals reduced Mdk RNA and protein expression at 3 (A) and 6 (B) months of age, respectively, relative to Nf1 OPG controls. Hoech
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Published: 12 April 2024
Figure 6. Clinically relevant pediatric LTR dosing suppresses tumor growth in two different Nf1 -OPG strains. (A) Schematic representation of mouse treatment and analysis timeline of Nf1 OPG mice. (B, C) Immunohistochemical staining (B) and RNA expression analysis (C) of Nf1 OPG retinae following LTR t
Journal Article
ACCEPTED MANUSCRIPT
Fariba Tohidinezhad and others
Neuro-Oncology, noae035, https://doi.org/10.1093/neuonc/noae035
Published: 10 April 2024
Journal Article
ACCEPTED MANUSCRIPT EDITOR'S CHOICE
Lakshmi Nayak and others
Neuro-Oncology, noae032, https://doi.org/10.1093/neuonc/noae032
Published: 10 April 2024
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Published: 10 April 2024
Graphical Abstract Graphical Abstract
Journal Article
Marjolein Geurts and Matthias Preusser
Neuro-Oncology, noae063, https://doi.org/10.1093/neuonc/noae063
Published: 09 April 2024
Journal Article
Isabel Arrillaga-Romany and Julie J Miller
Neuro-Oncology, noae051, https://doi.org/10.1093/neuonc/noae051
Published: 08 April 2024
Journal Article
ACCEPTED MANUSCRIPT
Elie Massaad and others
Neuro-Oncology, noae073, https://doi.org/10.1093/neuonc/noae073
Published: 06 April 2024
Journal Article
ACCEPTED MANUSCRIPT
Samuel S McAfee and others
Neuro-Oncology, noae070, https://doi.org/10.1093/neuonc/noae070
Published: 06 April 2024
Journal Article
ACCEPTED MANUSCRIPT
Denise Obrecht-Sturm and others
Neuro-Oncology, noae071, https://doi.org/10.1093/neuonc/noae071
Published: 05 April 2024
Journal Article
Neuro-Oncology, Volume 26, Issue 4, April 2024, Page 781, https://doi.org/10.1093/neuonc/noae023
Published: 05 April 2024
Journal Article
ACCEPTED MANUSCRIPT
Franz L Ricklefs and others
Neuro-Oncology, noae068, https://doi.org/10.1093/neuonc/noae068
Published: 03 April 2024
Journal Article
Hua-Qing Niu and others
Neuro-Oncology, noae050, https://doi.org/10.1093/neuonc/noae050
Published: 01 April 2024
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Published: 01 April 2024
Figure 1. (A) DEGs in individuals with skull base chordoma and spinal chordoma. (B) GO enrichment analysis of DEGs. (C) KEGG enrichment analysis of DEGs. DEGs, different expression genes; GO, gene ontology; KEGG, Kyoto encyclopedia of genes and genomes.