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Journal
Clinical Chemistry
Clinical Chemistry is a high-impact peer-reviewed publication, ranked as the most cited journal in the fields of clinical chemistry, clinical or anatomic pathology, analytical chemistry, transfusion medicine, and clinical microbiology.
Journal
The Journal of Applied Laboratory Medicine
The Journal of Applied Laboratory Medicine is an online-only, peer-reviewed
publication showcasing clinically relevant laboratory topics in applied and
translational research.
Journal Article
EDITOR'S CHOICE
MIQE 2.0: Revision of the Minimum Information for Publication of Quantitative Real-Time PCR Experiments Guidelines
Clinical Chemistry, hvaf043, https://doi.org/10.1093/clinchem/hvaf043
Published: 24 April 2025
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Accuracy assessment across sites. (A), Summary of assay performance measure... Get access
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Clinical Chemistry
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A Comprehensive Assessment of Metagenomic cfDNA Sequencing for Microbe Detection
Published: 24 April 2025
Fig. 2.
Accuracy assessment across sites. (A), Summary of assay performance measured by recall, precision, and F1 score; (B), Summary of false-positive results across laboratories; (C), False-positive microbes reported among 16 samples; (D), The top 15 false-positive microorganisms with the highest occurren
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Repeatability assessment across laboratories. (A), Repeatability in the det... Get access
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Clinical Chemistry
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A Comprehensive Assessment of Metagenomic cfDNA Sequencing for Microbe Detection
Published: 24 April 2025
Fig. 3.
Repeatability assessment across laboratories. (A), Repeatability in the detection of various microorganisms across 3 replicate samples by 130 laboratories; (B), Repeatability of microbial RPM values across various microorganisms in triplicate samples. *** P < 0.001 by Kruskal–Wallis tests; (C),
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The performance of metagenomic cfDNA sequencing in distinguishing genetical... Get access
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Clinical Chemistry
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A Comprehensive Assessment of Metagenomic cfDNA Sequencing for Microbe Detection
Published: 24 April 2025
Fig. 4.
The performance of metagenomic cfDNA sequencing in distinguishing genetically similar microorganisms. Scatter plots show the RPM value of each microbe reported by laboratories in (A) sample S4 (2-fold change of theoretical ratio 0.17–0.67), (B) S5 (2-fold change of theoretical ratio 0.50–2.00), and
Journal Article
A Comprehensive Assessment of Metagenomic cfDNA Sequencing for Microbe Detection Get access
Clinical Chemistry, hvaf044, https://doi.org/10.1093/clinchem/hvaf044
Published: 24 April 2025
Journal Article
The Need for Better Validation: Evaluating Aptamer and Proximity Extension Assays for Large-Scale Clinical Proteomics Studies Get access
Clinical Chemistry, hvaf046, https://doi.org/10.1093/clinchem/hvaf046
Published: 24 April 2025
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Summary of revisions and updates from previous guidelines ( 3 ).
in
Clinical Chemistry
>
MIQE 2.0: Revision of the Minimum Information for Publication of Quantitative Real-Time PCR Experiments Guidelines
Published: 24 April 2025
Fig. 1.
Summary of revisions and updates from previous guidelines ( 3 ).
Image
The multicenter quality assessment study design. In this study, a total of ... Get access
in
Clinical Chemistry
>
A Comprehensive Assessment of Metagenomic cfDNA Sequencing for Microbe Detection
Published: 24 April 2025
Fig. 1.
The multicenter quality assessment study design. In this study, a total of 18 reference samples were designed and distributed to 130 laboratories. Each laboratory conducted detection using their routine metagenomic cfDNA sequencing procedures and submitted their results to the National Center for Cl
Journal Article
Uric-a! Hyperuricemia in the Setting of Extreme Leukocytosis Get access
The Journal of Applied Laboratory Medicine, jfae166, https://doi.org/10.1093/jalm/jfae166
Published: 23 April 2025
Journal Article
In Reply to The Environmental Impact of Inappropriate Clinical Laboratory Testing: What’s New? Get access
The Journal of Applied Laboratory Medicine, jfaf051, https://doi.org/10.1093/jalm/jfaf051
Published: 23 April 2025
Journal Article
Commentary on Uric-a! Hyperuricemia in the Setting of Extreme Leukocytosis Get access
The Journal of Applied Laboratory Medicine, jfaf054, https://doi.org/10.1093/jalm/jfaf054
Published: 23 April 2025
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Timeline of select laboratory values. Trend in patient’s WBC (closed circle... Get access
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The Journal of Applied Laboratory Medicine
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Uric-a! Hyperuricemia in the Setting of Extreme Leukocytosis
Published: 23 April 2025
Fig. 1.
Timeline of select laboratory values. Trend in patient’s WBC (closed circles), serum uric acid (open circles), and eGFR (open triangles) 1 month prior to hospital admission (April) and throughout his hospital stay (May 1–June 4). Start of treatment, consisting of chemotherapy (hydroxyurea on May 2 a
Journal Article
The Environmental Impact of Inappropriate Clinical Laboratory Testing: What’s New? Get access
The Journal of Applied Laboratory Medicine, jfaf050, https://doi.org/10.1093/jalm/jfaf050
Published: 23 April 2025
Journal Article
Variants of Unknown Significance in Hyperlipidemia: A Diagnostic Quandary Get access
The Journal of Applied Laboratory Medicine, jfaf027, https://doi.org/10.1093/jalm/jfaf027
Published: 22 April 2025
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Temporal trends of outpatient median chloride levels from January 2017 to O... Get access
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The Journal of Applied Laboratory Medicine
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A Gradual Positive Bias in Chloride Measurements with a Major Automated Chemistry Platform
Published: 22 April 2025
Fig. 1.
Temporal trends of outpatient median chloride levels from January 2017 to October 2024 from patients and encounters with ICD-10 Z00.00. Horizontal dashed lines represent the upper and lower limit of the stated reference interval for chloride in the manufacturer’s IFU. A graph of median chloride r
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Bias plot between 4 indirect ISE peer group means and indirect ISE method m... Get access
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The Journal of Applied Laboratory Medicine
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A Gradual Positive Bias in Chloride Measurements with a Major Automated Chemistry Platform
Published: 22 April 2025
Fig. 2.
Bias plot between 4 indirect ISE peer group means and indirect ISE method means for specimens in the CAP C survey from 2019 to 2024. The horizontal dashed red line represents the calculated mean bias of 3.19 mmol/L for the Siemen Atellica platform.
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Lipid profile starting from first review in clinic. (A), Atorvastatin 20 mg... Get access
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The Journal of Applied Laboratory Medicine
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Variants of Unknown Significance in Hyperlipidemia: A Diagnostic Quandary
Published: 22 April 2025
Fig. 1.
Lipid profile starting from first review in clinic. (A), Atorvastatin 20 mg daily started; (B), atorvastatin increased to 40 mg daily; (C), ezetimibe 10 mg daily added; (D), atorvastatin increased to 80 mg daily. Abbreviations: TC, total cholesterol (mmol/L); TG, triglyceride (mmol/L); LDL-C, low-de
Journal Article
A Gradual Positive Bias in Chloride Measurements with a Major Automated Chemistry Platform Get access
The Journal of Applied Laboratory Medicine, jfaf046, https://doi.org/10.1093/jalm/jfaf046
Published: 22 April 2025
