Objective: The co-occurrence of multiple sclerosis (MS) with brain tumor (BT) has been reported, yet little is known about the relationship between these two central nervous system diseases. Overlapping presentation - both neuroimaging and neuropsychological profile - may complicate differential diagnosis. Method: This case reviews the medical and neuropsychological profile of a 52-year-old female who presented with rapidly progressing finger and toe numbness; difficulty chewing and dysphagia; altered gait; left hemispasticity, weakness and numbness; difficulty initiating voiding; Uthoff's phenomenon; difficulties with cognition and irritability; and headaches. Perceived cognitive changes included anxiety, distractibility, memory impairment, reduced multitasking, slowed processing, and apraxia. Given presentation and family history of MS, she was treated with methylprednisolone; however, symptoms progressed. MRI revealed an expansive, homogeneous, T2 and FLAIR hyperintense pontine mass extending into the ventral midbrain, with minimal scattered enhancement. Biopsy indicated BT (anaplastic astrocytoma) Neuropsychological evaluation was completed after histopathologic diagnosis. Results: Neuropsychological results...

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