Objective: White matter integrity (WMI) decreases in older adulthood. Lutein (L) and zeaxanthin (Z) are two carotenoids that diffusely accumulate in brain tissue and positively impact cognition. The current study tested the relation of L + Z to WMI using diffusion tensor imaging (DTI). Method: 38 younger (M = 20.54 years) and 54 older adults (M = 71.87 years) were recruited. Diffusivity was quantified as fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD). L + Z were measured via retinal (macular pigment optical density – MPOD) and blood serum levels. Hierarchical linear regression was conducted to predict diffusivity in global WM and 4 regions of interest (ROIs – genu of the corpus callosum, cingulum, uncinate fasciculus, and fornix) from L + Z and age group. Results: Age group, but not L...

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