Objective: Parkinson's disease (PD) impacts non-motor symptoms (NMS), including mood, cognition, and quality of life (QOL), however, evidence-based treatments are lacking. We evaluated the feasibility, tolerability, and efficacy of bio-psychosocial treatments in PD. Method: A randomized-controlled trial (RCT) of expressive writing (N = 27) compared effects of emotional or neutral writing on cortisol levels and NMS. An uncontrolled mindfulness-based intervention (N = 34) evaluated an eight-week program. A neurocognitive RCT (N = 32) compared memory and problem-solving interventions to supportive therapy. Another RCT (N = 25) compared two computer-based cognitive programs to an active control condition. Results: Feasibility and tolerability were high. Repeated measures analyses of variance were performed and p-values of significant effects are provided. In the expressive writing trial, emotional writing participants showed reduced cortisol levels (p = .049) and all participants experienced improved anxiety (p = .016), learning (p = .043) and memory (p = .001). In...

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