Objective: Among individuals living with HIV disease, approximately 60% evidence everyday functioning impairment. This rate of impairment highlights the need to reliably assess everyday functioning problems in clinic. The present study aimed to investigate the utility of the UCSD Performance-based Skills Assessment-Brief Version (UPSA-B) as a measure of everyday functioning capacity in HIV. Method: We utilized a cross-sectional three-group design comparing individuals with HIV-associated neurocognitive disorder (HAND; n = 27), HIV+ neurocognitively normal individuals (n = 51), and an HIV- comparison group (n = 28) with broadly comparable demographics and non-HIV comorbidities. Participants were administered the UPSA-B, the Medication Management Test (MMT), which is an everyday functioning capacity measure previously validated in HIV, and the Short-Form Health Survey, as part of a standardized clinical neurocognitive research battery. Results: A Wilcoxon rank sum test revealed that the HAND group had significantly lower UPSA-B scores than the neurocognitively normal HIV+ group (p...

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