Objective: Multiple concussions sustained in youth may be associated with later-life brain changes and worse cognitive outcomes. We examined the association between sustaining two or more concussions in the context of high school football and later-life white matter (WM) microstructure using diffusion tensor imaging (DTI). Method: Forty, right-handed former high school football players currently ages 40-65 were divided into two groups: those who received two or more concussions in the context of high school football (n = 20), and those who denied concussive-like events but were matched on age, education, and premorbid intellect (n = 20). Participants underwent neurocognitive testing and a DTI scan on a 3-Tesla magnet. Results: Tract-based Spatial Statistics yielded several areas of lower fractional anisotropy (i.e., worse overall WM integrity) in the concussed group at a threshold of p < .05, corrected for multiple comparisons. These areas included the corpus callosum, superior longitudinal fasciculus, and internal...

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