Objective: Determine the ability of a novel computerized paired-associate test to identify subtle cognitive impairments related to mild cognitive impairment (MCI) and cognitively normal (CN) subjects in the population.

Method: CN (n = 64) and MCI (n = 34) subjects were administered the MITSI-L, a brief and sensitive computerized verbal paired-associate test to determine the strength of memory binding of semantically related word pairs, as well as a proactive semantic interference. A series of ANOVAs were run to evaluate differences in performance on the MITSI-L task. Logistic Regression and Receiver Operator Curves (ROC) analysis were used to further determine discriminative validity. Results: Relative to CN individuals, MCI participants had lower scores on all MITSI-L indices. Logistic regression showed that a combination of two specific paired associate scores positively identified 85.3% of MCI individuals and 84.4% of CN individuals. The ROC curve demonstrated that the combined MITSI-L score was a stronger...

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