Objective: To evaluate differences in proactive interference among persons with amnestic MCI (aMCI) and cognitively normal elderly (CN) and to determine the extent to which MRI measures sensitive to early Alzheimer's Disease (AD), are associated with these indices. Method: Thirty-six older adults (15 aMCI) and (21 CN) were administered the LASSI-L, a test that yielded indices of maximum learning, vulnerability and recovery from proactive interference and susceptibility to retroactive interference. Upon completion of the LASSI-L, patients underwent an MRI scan. Results: aMCI individuals had lower scores on the LASSI-L A with regards increased vulnerability to proactive semantic interference (PSI) impaired recovery from PSI and vulnerability to retroactive interference. Among those participants with memory impairment, Spearman Rank Order Correlation Coefficients indicated a different pattern of brain-behavior relationships. LASSI-L B cued recall, a test sensitive to vulnerability to PSI was highly related to dilatation of the left lateral ventricle (r = .56,...

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