Objective: Amnestic MCI (aMCI) is a risk factor for AD. Problems with PSI are believed to account for early deficits in aMCI, although it can also be argued that PSI deficits merely reflect a generalized deficit in learning and retrieval. This study evaluates the usefulness of the Loewenstein-Acevedo Scales of Semantic Interference and Learning (LASSI-L) in predicting early AD. Method: 28 aMCI and 56 cognitively-normal (CN) elders (N = 74) were administered the LASSI-L, a novel test that measures maximum learning capacity and PSI. Participants were presented with List A (15 semantically related words: fruits, musical instruments, and articles of clothing), followed by List B, a semantically-similar wordlist. After assessing PSI effects, participants were once again presented with List A to evaluate recovery from PSI. Delayed recall was also assessed. Results: After adjustment for age, MMSE scores, and the ability to learn List A, aMCI participants had lower free recall...

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