Objective: Mild Cognitive Impairment (MCI) is a known risk factor for the development of Alzheimer's disease (AD). It has been shown that both vulnerability to proactive semantic interference (PSI) and lack of recovery from PSI have strong relationships with brain amyloid load among community-dwelling elderly subjects. However, the Loewenstein-Acevedo Scales of Semantic Interference and Learning (LASSI-L) have not been related to MRI evidence, a sophisticated biomarker of actual neurodegeneration within the brain. Method: Thirty-two older adults with MCI and 44 cognitively normal (CN) participants (N = 76) were administered the LASSI-L, a novel list-learning test that is sensitive to PSI deficits and ability to recover from PSI. Performance on the LASSI-L and other memory measures (HVLT-R and Logical Memory) were compared to hippocampal volumes and dilatation of the inferior lateral ventricles, which are two noted changes that occur in early AD. Results: The HVLT-R and LASSI-L recovery from PSI most...

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