Objective: To examine whether differences in regional cerebral blood flow (rCBF) exist in male versus female children diagnosed with ADHD at baseline. Method: A clinical sample of 1,619 individuals who received a diagnosis of ADHD from a large de-identified database were given a single photon emission computed tomography (SPECT) scan as part of a comprehensive evaluation. Participants included 889 males and 730 females with a mean age of 13.07 years (SD = 3.20). Blood flow was measured at baseline in 17 brain regions. Results: MANOVA yielded significant differences at p < .05 in blood flow between males and females with ADHD, Wilks’ λ = .646; F(2, 1619) = 54.950, p < .001. Specifically, males yielded significantly lower blood flow in the basal ganglia, left frontal lobe, limbic system, motor-sensory cortex, and unilateral vermis. Females, however, yielded significantly lower blood flow in the cerebellum, right frontal lobe, occipital lobe, parietal lobe,...

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