Objective: Depressive symptoms are common in dementia, and some studies have cited a history of depression (HxDep) as a risk factor for Alzheimer disease (AD). Depression has also been associated with earlier onset of dementia, although little is known whether this is related to other factors or is a result of cognitive decline. We examined whether HxDep was associated with an earlier age of AD diagnosis, after controlling for known risk factors in a large national sample. Method: National Alzheimer's Coordinating Center data were obtained for AD subjects with a reported HxDexp (HxDep+) or without a reported HxDep (HxDep–). Those who reported depression within two years were excluded. Sociodemographic and clinical factors were assessed using independent t- and chi square tests. HxDep+ and HxDep– groups were compared via ANCOVA on age of AD diagnosis, while accounting for various demographic/medical factors. Results: Sex, apolipoprotein E4 status, Mini Mental State Examination scores,...

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