Objective: Depression and anxiety are the most common psychiatric disorders in patients with epilepsy. Although depression and anxiety are reported to be prevalent both before and after surgical intervention, there is a lack of research assessing the relationship between seizure location and changes in mood states in patients with epilepsy. In this study, we examine the association between seizure location and depression and anxiety in pre and postoperative temporal lobe epilepsy (TLE) patients. Method: The study consisted of 39 patients with TLE (23 right TLE, 16 left TLE) who underwent a temporal lobectomy and had a neuropsychological evaluation before and after surgery. Depression scores, as assessed by the Beck Depression Inventory-II (BDI-II), and anxiety scores, as assessed by the State and Trait Anxiety Inventory (STAI), were examined in both pre and post surgical evaluations. Multivariate analysis of variance was used to identify interactions between both affective means and location of...

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