Objective: To investigate whether the use of cocaine affects cerebral blood flow. Method: Individuals with high reported levels of cocaine use (n = 103) who had a mean age of 37.29 (SD = 11.89) and individuals with no reported levels of cocaine use (n = 85) with a mean age of 44.11 (SD = 16.67) were given a single photon emission computed tomography (SPECT) scan as part of a comprehensive evaluation with data generated for seventeen areas within the brain. Results: A MANOVA conducted at the .01 level yielded significant differences between participants with high reported levels of cocaine use and those with no reported usage, Wilks λ = .743; F (17, 170) = 3.466, p < .001. Participants with high usage exhibited decreased blood flow relative to participants without cocaine use disorder within the left and right limbic lobe as well as the left and right basal ganglia. Conclusion:...

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