Objective: To compare SPECT at-rest blood perfusion across 17 brain regions, between Alcohol-Related Disorder, Cannabis-Related Disorder, and a no diagnosis group. Method: Participants from a clinical database (74.4% male, Mage = 35.77 years, SD = 14.42) were selected based on Alcohol-Related Disorder (n = 747), Cannabis-Related Disorder (n = 602), or no diagnosis (n = 83). Results: MANOVA conducted at alpha = 0.001 revealed significant group differences, Wilks’ Λ = 0.835; F(32, 2828) = 8.32, p < 0.001. There were significant differences in bilateral limbic, basal ganglia, cerebellum, frontal, occipital, motor/sensory, and parietal regions, as well as the right temporal lobe and the vermis. In the limbic and basal ganglia lobes bilaterally, and in the vermis, blood perfusion was highest in the no diagnosis group, and lowest in the cannabis-disorder group, but perfusion...

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