Objective: To examine the relationship between oxidative stress-related conditions and cognitive change in a longitudinal Parkinson's disease (PD) cohort. Method: Fifty-six individuals with PD [Mage = 64.79(9.49); Meducation = 16.00(2.78); MPD duration = 3.64(1.59)] underwent cognitive assessment at baseline (T1) and 5 years (T2) as part of a larger study. Cognitive variables included: Wechsler Adult Intelligence Scale–III Block Design and Digit Span, FAS, Animals, Stroop Neuropsychological Screening Test , Rey-Osterrieth Complex Figure (Rey-O; copy, immediate, and delayed), and Hopkins Verbal Learning Test–Revised. Elevated plasma homocysteine (elHCY>14µmol/L) was determined at T1 via phlebotomy. At T2, participants reported past or present diagnosis of: hypertension, hyperlipidemia, diabetes, cancer, and rheumatic disease. Stepwise regressions were conducted for each cognitive measure, with change score (T2-T1) as the outcome variable. Predictors included oxidative stress-related conditions and potential confounding variables (age, education, and PD duration). Bonferroni correction for multiple comparisons resulted in a significance threshold of p...

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