Objective: Genetic influences on post-concussion neurocognitive performance are not well understood, especially the relationship between genetics and intraindividual cognitive variability. The purpose of this study was to determine whether the e4 allele of the APOE gene impacts neurocognitive performance variability following concussion in a sample of college athletes. It was hypothesized that concussed athletes with an e4 allele would show greater performance variability than those without an e4 allele. Method: Participants were comprised of 60 concussed athletes (76.7% male) who participated in a concussion management program. All athletes underwent a comprehensive neuropsychological assessment and provided a DNA sample for determination of their APOE genotype. Two measures of variability were computed: a range score, calculated by taking the difference between each athlete's highest and lowest standard scores across the test battery and an average standard deviation (ASD) score across all tests. Results: The sample was divided into e4+ (n = 20)...

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