Objective: Determine factors that affect responsiveness to cognitive rehabilitation (CR) interventions in Service Members (SM) who sustained mTBI. Method: 126 SM with a history of mTBI who were 3 to 24 months post-injury participated in this randomized clinical trial (RCT) of one of four, 6-week treatment arms: 1) psychoeducation, 2) computer-based CR, 3) therapist-directed manualized CR, and 4) therapist-directed CR integrated with cognitive behavioral psychotherapy. Practice-adjusted reliable change scores (RCS) at the 90% confidence interval were calculated for the three primary outcome measures: Paced Auditory Serial Addition Test (PASAT); Symptom Checklist – 90 Revised (SCL-90-R) Global Severity Index (GSI); Key Behaviors Change Inventory (KBCI). Hierarchical logistic regression was used to predict RCS. Variables were entered in the following order: (a) demographic, (b) injury characteristics, (c) comorbid mental health conditions, (d) patient motivation, (e) non-specific treatment variables (e.g., Team versus No-Team Milieu), and (f) specific treatment elements (hours of individual and...

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