Objective: Little is known regarding cortical reorganization following limb transplantation compared to central nervous system insults such as stroke. This longitudinal case study examined the pattern of neural synchrony using magnetoencepaholography (MEG) over 12 months. We hypothesized that reorganization would proceed from enhanced connectivity in sensory regions followed by motor consistent with a model of afferent prior to efferent regeneration. Method: A 24-year-old male underwent a right hand allotransplant. He underwent MEG (306-channel Elekta-Neuromag) at 11 time points over one year. ECG and movement artifacts were removed using ICA. Data were band-pass filtered 3 to 85 Hz and sampled at 508.63 Hz. Synchronization of neural activity during rest was quantified by calculating coherence between cortical sites using MR-FOCUSS. We focus on the top regions of highest coherent activity at each time point. Results: Initially, post transplantation, the strongest coherent activity was between parietal and temporal regions, while less robust connectivity...

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