Objective: Many individuals with multiple sclerosis (MS) report feeling stigmatized (Cook, Germano, & Stadler, in press), but little research has examined the psychological impact of this. Given the high prevalence of depression in MS, the aim of the current study was to assess, cross-sectionally and prospectively, the relationship between stigma and depression in people living with MS. Method: Data were collected from 5,104 people living with MS as part of the semi-annual survey conducted by the North American Research Committee on Multiple Sclerosis (NARCOMS). Participants’ perceptions of stigma and their ratings of depression were collected in spring 2013; one year later ratings of depression were collected again. Two subscales assessed stigma: Target-Stigma (e.g., “Because of my MS, I worry about people discriminating against me”) and Isolation-Stigma (e.g., “Because of my MS, I feel left out of things”). Hierarchical linear regressions tested stigma's contribution to depression both concurrently and prospectively, while...

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