Objective: There is a growing literature describing the cognitive changes associated with Fragile-X permutation carrier status, though most research to date has been in male carriers who are more likely to develop Fragile-X Associated Tremor/Ataxia Syndrome (FXTAS), a progressive neurodegenerative condition. Females are less likely to develop FXTAS and accompanying dementia, but have higher rates of depression and immune-related disorders. While memory decline and executive dysfunction in male carriers is documented, there is mixed evidence of cognitive changes in female permutation carriers, with some studies showing no changes and others showing subtle declines. Here we describe a case of a 50 year-old Caucasian female who presents with symptoms related to FXTAS, including tremor, gastrointestinal symptoms, and reported cognitive changes. Method: Genetic testing confirmed permutation carrier status of CGG trinucleotide repeats (32 & 80)....

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