Objective: The second-generation anti-psychotics were introduced in the early 1990’s and can be divided into three categories: the –pines, the -dones, and the –pips. While there has been considerable research into the impact of these drugs on positive symptoms, no research has as yet compared them in terms of their cognitive efficacy. Data Selection: Comprehensive search of the Medline and PsycINFO computerized data-bases was conducted to identify studies that examined the efficacy of atypical-antipsychotics in treating the cognitive deficit in schizophrenia patients between the 1st of January 1990 and the 23rd of November 2015 (date of last update). Boolean search terms included working memory, auditory memory, ziprasidone, iloperidone, paliperidone, lurasidone, asenapine, and brexipiprazole. Only human studies and papers written in English were used. Data Synthesis: A total of 12 studies met the inclusion criteria and 8 cognitive domains were assessed: attention, executive functioning, motor function, non-verbal memory, processing speed, verbal...

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