Many pathognomonic indicators of brain damage are characterized by deficits in sensory and/or motor functions. The strength of these pathognomonic signs has led to reliance on clinical administration and interpretation in the assessment of sensory and motor functions. Subsequently, the majority of measures designed to assess sensory and motor functions lack adequate reliability and psychometric confirmation of their utility. The Dean-Woodcock Sensory-Motor Battery (DWSMB) was designed to standardize the administration and interpretation of sensory-motor functions and has demonstrated satisfactory reliability. The present study further examined the psychometric properties of the DWSMB through factor analysis. It was hypothesized that at least two factors would emerge representing sensory and motor functions, respectively. A third possible factor that would reflect subcortical functioning was also hypothesized. Principal components analysis on data from over 600 participants supported a three-factor solution which accounted for 50.9% of the total variance. However, factor loadings revealed more dual loadings than expected, and factors emerged according to complexity rather than basic sensory, motor, and subcortical factors. Regardless, these data provide empirical evidence for the conceptualization of sensory-motor skills in a manner that incorporates subcortical abilities. These data also provide support for the underlying constructs of the DWSMB.