Changes in personality and emotional status are common in individuals with multiple sclerosis (MS). The purpose of this study was to examine results based on the MMPI-2 before and following application of a statistical correction procedure (Gass, 1992). This was done to help determine changes in scale score elevations when items containing actual physical symptoms are identified and statistically removed. Twenty-eight participants with MS were administered the MMPI-2, then retested 1 year later. Stability of MMPI-2 scores over time was demonstrated. Results showed that when the correction procedure was applied to the MMPI-2, eight standard clinical scale scores dropped an average of 6.66 T-score points. Significant differences were obtained between standard MMPI-2 scored profiles and corrected profiles on Scales 1–3 and 8. Cautious interpretation of MMPI-2 results for neurological samples was indicated. This study extended prototypic research by using patients with MS, examining the stability of results over time (1 year), and introducing a more reliable method of deriving standard T-scores in the correction procedure.