The objective of this study was to examine differences between fluent English-speaking ethnically diverse (ED) individuals (from Hispanic, Asian and Middle-Eastern descent) and monolingual English-speaking Anglo-Americans (MEAA) on commonly used tests of information processing and attention. A sample of 123 (84 ED and 39 MEAA) healthy individuals participated. The results revealed that the MEAA group outperformed the ED group on Trail Making Test Part B, Stroop B and C, and Auditory Consonant Trigrams (18s delay condition). Additionally, a host of acculturation variables such as score on a formal acculturation scale, amount of time educated outside of the U.S., and the amount of English spoken when growing up correlated with these various neuropsychological tests. The findings from this study highlight the importance of taking acculturation into account for fluent English-speaking ED individuals when administering and interpreting neuropsychological tests.