Objective: Children with central nervous system (CNS) tumors or those receiving CNS toxic cancer treatments are at risk for cognitive dysfunction. The pediatric Functional Assessment of Chronic Illness Therapy - Perceived Cognitive Function (pedsFACIT-PCF) is a 5-minute cognitive screening test completed by parents to determine if their children require a comprehensive neuropsychological testing in clinical settings. We evaluated the equivalence of the pedsFACIT-PCF items by language of administration (English versus Spanish). Method: Thirteen pedsFACIT-PCF English language items with 5 response choices were translated into Spanish. A total of 1358 English speaking (children mean age = 12.5 years; 57% male) and 604 Spanish speaking (children mean age = 12.3 years; 54% male) parents completed pedsFACIT-PCF items by their primary language. Psychometric properties of Spanish language items were estimated. Responses to the pedsFACIT-PCF were modeled using item response theory in which the presence and impact of differential item functioning (DIF) by language of administration was evaluated. Results: Item means ranged from 3.69 (SD = 1.09) to 3.95 (SD = 1.13). Coefficient alpha was 0.97, and item-rest correlations ranged from 0.79 to 0.86. A one-factor model fits the data relatively well (CFI = 0.997, TLI = 0.996, and RMSEA = 0.067). The slope parameters ranged from 3.01 to 4.12. The threshold parameters ranged from −2.13 to 0.72. Conclusion(s): The pedsFACIT-PCF has good reliability and validity, which appears to measure cognitive function equivalently in Spanish and English. It is a promising tool to screen children for a comprehensive neuropsychological testing.