Objective: This case study explores the neuropsychological functioning of three cases of agenesis of corpus callosum (ACC) in active duty service members. ACC is a common congenital abnormality that occurs in about 0.7% of all births and typically identified only when some other condition brings them to a neurologist's attention as they typically do not demonstrate neurological or neuropsychological defects. However, some studies have demonstrated that most cases of ACC have some form of psychiatric disorder, neurological condition, and/or intellectual impairment. A review of the literature does not demonstrate a prototypical neuropsychological profile, but does suggest that this condition typically demonstrates deficits in motor and perceptual-motor functioning. This study expounds on the literature by discussing this neurological condition in the context of an evaluation to determine disability compensation. Method: All cases initially presented to a neurologist with either new onset of migraine headache or new onset of seizures. MRI results confirmed the ACC. Results: Though they passed stand-alone symptom validity tests (SVT) all cases failed at least one embedded SVT. There was no common pattern amongst the cases and their cognitive scores were far below their current level of functioning in everyday life. Two of the three cases produced questionable MMPI-2 profiles with all three cases only elevating scale 8 to a clinically significant level. Conclusion(s): These cases highlight the need for neuropsychological evaluation when determining compensation in those with ACC.