Objective: This presentation will review the follow-up case information of 14 children with Landau-Kleffner syndrome (LKS), the most prominent feature of which is acquired aphasia. The neuropsychological profiles are considered in the context of neurological and syndrome-related factors. Method: This is a retrospective study of 14 cases of children with LKS followed at a tertiary care pediatric epilepsy center. From the research data base, all LKS cases with neuropsychological evaluation were extracted. Children ranged in age from 6 to 13 years (M = 9.12; SD = 2.19) at the time of assessment (1 to 10 years post-onset). The majority of the children were white males, and all but one continued to experience seizure activity. Global functioning ranged from 59 to 101 (M = 82.07; SD = 12.14). In addition to neuropsychological test results, information on age of onset, duration, seizure type, medication status, and localization-related information based on neurological records were considered. Results: Across the 14 cases reviewed, 86% demonstrated expressive and 50% had receptive language problems with 57% exhibiting poor auditory processing. Further, 50 to 57% had deficits in auditory working memory and verbal memory. Notably, 43 to 50% presented with visual-spatial/constructional deficits and 36% had deficits in visual memory. Academically, the majority had poor reading fluency and comprehension; 50% exhibited difficulty with mathematics. Finally, 57% evidenced attentional or other behavioral problems. Conclusion(s): For this group of children with LKS, consistent findings were higher levels of linguistic, verbal memory and academic problems, in addition to behavioral problems. Better understanding of LKS can assist in targeted assessment and intervention planning.