Objective: Connor's Continuous Performance Test-II (CPT-II) is widely used as a measure of sustained attention and has shown sensitivity to impairment in several clinical populations. As factor structure of assessment tools may vary across clinical populations, the current study aims to extend our prior findings by examining the factor structure of the CPT-II in a sample of children who have sustained traumatic brain injury (TBI) and compare it to other pediatric populations, including a sample of kids and adolescent with mixed diagnoses (MD), a normal control sample (NC), and a sample of the all of the groups combined. Method: There were 392 individuals with a clinical diagnosis (132 female; mean age = 12.4). Of the clinical population, 185 sustained a TBI (77 female; mean age = 13.6). The NC sample had 246 children and adolescents (93 female; mean age = 12.4). Results: Confirmatory factor analyses indicated that the unitary, three factor, and four factor solutions fit all of the samples poorly. Thus, follow up exploratory factor analysis (EFA) was conducted. Principle component analyses of the CPT-II indicated a three factor solution in all of the samples. Consistent with our prior work, the factors appeared to represent Inattention, Impulsivity, and Vigilance. Conclusion(s): While CFA analysis indicated poor fit of the data, the EFA yielded consistent results across the entire sample, MP, and NC. With the exception of differences in of the loading of Perseverations, the EFA of the TBI sample was consistent with the structure found in the other samples.