Objective: Functional neuroimaging studies strongly implicate involvement of the orbital frontal cortex (OFC) in emotional control (EC) through its connectivity to the limbic system (Banks et al., 2007), but Welborn et al. (2009) found that volumetric differences in the OFC were not related to EC in adults. This study examined the relationship between OFC volume and EC in children. Method: As part of a larger study on a community sample, 98 children (ages 8–12 years) with ADHD, reading disabilities, both disorders, and controls underwent a T1-weighted MRI scan and neuropsychological testing. Parents and teachers completed questionnaires, including the Emotional Control scale from the Behavior Rating Inventory of Executive Function (BRIEF). The OFC was manually traced in the coronal plane using the Analyze 11.0 ROI module in order to determine its gray matter volume after attaining inter- and intra-rater reliability (r > .9) Results: Due to the dearth of research in this area, an exploratory backward linear regression was used to predict parent-rated emotional control. The model was significant, adjusted R2= .12, F(3, 94)= 5.42, p = .002, with ADHD diagnostic status, β = .28, t(94) = 2.95, p = .004, left OFC volume, β = −.25, t(94)= −2.50, p = .01, and gender, β = .18, t(94) = 1.74, p = .09, being the final predictors. Right OFC was removed from the equation. Very similar results were found for teacher reported EC, except that gender was excluded from the final equation along with right OFC volume. Conclusion: Our study contributes to the literature suggesting that the OFC plays a role in emotional control.
Larger Left Orbital Frontal Cortex Volume Is Related to Better Emotional Control in Children
S Dyer, S Vadnais, S Lee, J Constance, M Kibby; Pediatrics-3
Larger Left Orbital Frontal Cortex Volume Is Related to Better Emotional Control in Children. Arch Clin Neuropsychol 2015; 30 (6): 481-482. doi: 10.1093/arclin/acv046.19
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