Objective: To investigate the effect of cerebral blood perfusion as a result of amphetamine disorders during the Connors Continuous Performance Task (CPT). Method: One hundred and nine participants, 24% female and 76% male, with amphetamine disorder, with a mean age of 42.84 (SD = 17.15) and 94 controls, 56% female and 43% male, with a mean age of 33.21 (SD = 10.69) between the ages of 18 and 84 from outpatient clinics were administered a SPECT scan during baseline and during concentration on the CPT. Results: Independent samples t-tests were conducted at the p < .001 level, revealing statistically significant decreases in blood perfusion in participants with amphetamine disorder compared to control group. Deficits were prevalent in bilateral limbic regions, basal ganglia and vermis. During the concentration task, results were consistent at baseline for the vermis, p = .000, and right limbic area, p = .000, but inconsistent for the left limbic region, p = .002, and basal ganglia (p = .003; p = .004). The left limbic and basal ganglia regions indicated increased blood flow, yet approaching statistical significance. Conclusion: These findings suggest habitual amphetamine use will result in deficits to regions of the brain involved with learning new tasks, eye movement control, and postural stability. During tasks of increased concentration, individuals with amphetamine disorders presented with decreased blood flow to the right limbic area and vermis. Reduced blood flow in these areas suggests that individuals with amphetamine disorders experience a decrease in motor control, sustainment of attention, and stimuli focus.