Objective: The current study examined yes/no recognition memory and cued recall in Parkinson's disease (PD) patients with normal cognition (PDNC), mild cognitive impairment (PD-MCI), dementia (PDD), and a healthy comparison (HC) group using the California Verbal Learning Test-2 (CVLT-2). Method: The Mattis Dementia Rating Sale (MDRS) determined global cognitive status. The PDNC group (n = 114) had MDRS scores > 137, PDMCI (n = 81) had scores between 137 and 125, PDD (n = 19) had scores < 124, and all HC participants (n = 56) had scores > 137. Groups were compared on Cued Recall Discriminability (CRD) and Recognition Discriminability (RD) indices. One-way Analysis of Variance was used to compare the four groups, LDS tests were used for post hoc comparisons, and p < .05 level was considered significant. Groups differed in age and gender (chi square), thus age- and gender-corrected standard scores were used from the CVLT-2. Results: Groups differed significantly on both the CRD (HC = PDNC > PDMCI > PDD) and RD (HC > PDNC > PDMCI > PDD), but only the RD index was able to discriminate between HC and PDNC. Conclusion: Yes/no recognition memory was sensitive to cognitive functioning in patients with PD at all stages of global cognitive status in that it differentiated between HC and all PD subgroups, regardless of global cognitive functioning. In contrast, cued recall did not differentiate between HC and PDNC, but it did discriminate between these two groups and the PDMCI and PDD groups. Yes/no recognition testing is more sensitive to the early cognitive changes observed in patients with PD.
The Impact of Reduced Retrieval Demands on Verbal Memory in Parkinson's Disease Patients at Various Levels of Global Cognitive Functioning
M Hernandez-Mejia, B Prendiville, C Fong, M Burke, L Nguyen, D Schiehser, E Turk, D Delis, J Filoteo; A-27
The Impact of Reduced Retrieval Demands on Verbal Memory in Parkinson's Disease Patients at Various Levels of Global Cognitive Functioning. Arch Clin Neuropsychol 2015; 30 (6): 495. doi: 10.1093/arclin/acv047.27
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