Objective: Investigated how cerebral blood flow (CBF) is related to low and high endorsement of levels of borderline personality disorder (BPD) symptoms at baseline and while concentrating. Method: Participants from an archival de-identified database received symptom checklists and a single photon emission computed tomography (SPECT) scan as part of a comprehensive evaluation both at rest (baseline) and while taking the CPT (concentration). Participants were chosen based on their self-reported answers on 35 questions measuring BPD symptoms and included 4383 individuals with low endorsement as well as 4428 individuals with high endorsement. Average age was 40.9 years (SD = 16.05) with 58.1% males and 41.9% females. Results: At the .01 level, t-tests revealed statistically significant differences. During concentration, the high endorsement group had decreased CBF in the right and left hemispheric occipital lobe, vermis, and right temporal lobe. During baseline, the high endorsement group had decreased CBF in right and left hemispheric basal ganglia, cerebellum, occipital, temporal and parietal lobe as well as vermis. Conclusion: The SPECT imaging results indicate that individuals who endorse more BPD symptoms may have issues with sensory-related aspects such as balance and vision while concentrating and at rest. BPD symptomatology appears to have a greater affect on the posterior area of the brain, as CBF did not reveal significant differences in the frontal lobe, which indicates executive functioning was not affected.
NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS: PSYCHIATRIC ILLNESS
An Exploratory Analysis of Regional Cerebral Blood Flow in Borderline Personality Symptoms using SPECT
M Blose, C Golden, D Amen, K Willeumier, D Taylor; NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS: PSYCHIATRIC ILLNESS
An Exploratory Analysis of Regional Cerebral Blood Flow in Borderline Personality Symptoms using SPECT. Arch Clin Neuropsychol 2015; 30 (6): 497. doi: 10.1093/arclin/acv047.31
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