Objective: To assess which brain areas, as measured by SPECT, were related to self-reported depression-like symptomatology. Method: Using a symptom checklist, participants were determined based on their score of a scale measuring self-reported depression-like symptomatology. These participants were part of a large archival de-identified database. There were a total of 7564 participants (age: M = 41.18, SD = 16.01; 58% males, 69% Caucasian), categorized into a low depression (those below one standard deviation) and high depression group (above one standard deviation). Measurements were analyzed in 17 areas across the brain. Results: A MANOVA was conducted at the participants' baseline and concentration levels at the ≤.05 level. MANOVAs for both baseline and concentration were significant. At baseline, there were significant differences in the Basal Ganglia-R, Frontal-L, Frontal-R, Occipital-L, Occipital-R, Motor Sensory-L, Motor Sensory-R, and Temporal-R areas, in which the high depression group had lower levels of cerebral blood perfusion concentration, there was only a significant difference in the right limbic system (high depression group was lower). Conclusion: Depression severity at rest is related to an overall decrease in cerebral blood perfusion, accounting for the variety of symptoms experienced by depressed individuals, such as the diminished ability to think or concentrate or feelings of indecisiveness (related to the frontal lobe) and psychomotor retardation (related to motor-sensory areas). During the concentration phase, they are able to focus the areas when required to concentrate on a specific task, showing that the deficit can be overturned with effort, although the effort is likely greater for these individuals who start at rest at lower levels than with normal individuals.