Objective: Deficits in serial order processing information in working memory have been reported in schizophrenia, however, it is unclear what specific components of working memory are contributing to this deficit. The present study utilized a novel order reconstruction task to examine working memory for serial order processing in greater detail. Specifically, the integrity of serial position information was assessed when retrieval demands for spatial location were minimized. Method: Schizophrenia patients (n = 19) and demographically similar healthy controls (n = 38) were assessed for overall accuracy on a novel order reconstruction task in which five to six targets were presented sequentially on a grid. Participants were then instructed to select the items in the order presented. To minimize retrieval demands when participants were responding, all targets were presented simultaneously. Results: Both groups demonstrated similar performance profiles, with patient performance attenuated compared to controls. Specifically, patients demonstrated lower overall accuracy regardless of the number of targets [Five targets: F(1,55) = 7.05, p = .01; Six F(1,55) = 4.55, p < .05]. Conclusion: On a simplified task that reduced retrieval demands by providing spatial locations of targets, schizophrenia patients showed robust impairments for reconstructing a sequence. Thus, working memory deficits for serial position may not be complicated by retrieval demands, but could be disrupted at an earlier or more basic level. These findings suggest that deficient sequencing may be a fundamental component of working memory dysfunction in schizophrenia that contributes to more general working memory impairments.
Order Reconstruction without Item Specific Retrieval Demands is Deficient in Schizophrenia
T Carrathers, J Roseberry, S Hill; A-39
Order Reconstruction without Item Specific Retrieval Demands is Deficient in Schizophrenia. Arch Clin Neuropsychol 2015; 30 (6): 500. doi: 10.1093/arclin/acv047.39
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