Objective: Investigate the relationship between lesion location on MRI and performance on the Rey Complex Figure Test – Copy (RCFT). We hypothesized that, as in stroke patients, there would be a strong relationship between lesion location and performance on the RCFT in traumatic brain injury (TBI) patients. This study is important because the generalizability of findings on RCFT to a variety of disorders is clinically relevant. Method: Subjects were between 30 days and 2 years post-TBI and had an brain lesion on imaging. Brain lesions were categorized as either left or right hemisphere and anterior or posterior. Those with lesions that included multiple quadrants were considered “global” injuries. Results: 39 subjects (67% male, average age 44.6 years and education level 15.4 years) were enrolled. Subject lesions were categorized as follows: 28% left, 26% right, 46% global; 46% anterior, 10% posterior, 44% global. Those with left hemisphere lesions scored significantly lower on the RCFT - Copy score (average 7.7 points lower; p < .001). However, there was no relationship between lesion location and the type of error (“Accurately Drawn”/“Correctly Placed”). Analyses employed 95% confidence intervals. Conclusion: Our findings differ from those in stroke. The stroke literature suggests an association between right hemisphere lesion and lower Copy scores. However, we found that in TBI there was an association between left hemisphere lesions and lower copy scores. Furthermore, we found no relationship between lesion location and type of error. These findings do not support the extension of the stroke literature to that of TBI with respect to the RCFT.