Objective: Although the MoCA has gained tremendous popularity, validation studies for its use in brain-injured (ABI) patients are limited. This is the first study to determine the utility of the MoCA in ascertaining the extent of cognitive impairment in ABI patients, and how it relates to self-reported cognitive, physical and affective symptoms using the Problem Checklist (PCL). Method: One hundred and nine ABI patients referred for physiatry assessment in a rehabilitation outpatient hospital clinic completed both the MoCA and the 43-item PCL at their initial visit. Anova, correlational and qualitative analyses were conducted to determine the relationship between MoCA scores and the frequency and severity of self-reported ABI symptoms. Results: MoCA scores ranged from 7 to 30, with the lower quartile falling at 21, and the upper quartile falling at 26. Patients with more significant cognitive impairment reported more ABI symptoms, particularly physical symptoms. Although all patient groups reported some cognitive difficulties, a greater proportion of patients with normal MoCA performance reported problems with memory and distractibility. Depression was more frequently reported by patients with either severe cognitive difficulties or with no cognitive impairment. The Abstraction and Delayed Recall items on the MoCA were less well performed and distinguished patients with minimal cognitive impairment. In contrast, difficulties on the Orientation items depicted more severe cognitive impairment. Conclusion: The findings of this study are generally consistent with those of previous research. The MoCA appears to be an efficient cognitive screening tool and its utility in determining treatment options for ABI patients will be discussed.