Objective: Individuals with traumatic brain injury (TBI) and co-occurring spinal cord injury (SCI) often face complex neuromedical difficulties and cognitive/behavioral disabilities that may impact their rehabilitation and short/long-term functional outcomes. The literature is insufficient regarding effective treatments for these individuals. The objective of this study is to review the feasibility and efficacy of cognitive rehabilitation (CR) and skill-based therapies among individuals with acute SCI and mild-to-moderate TBI. Method: We conducted a qualitative analysis of the literature consisting of 20 peer-reviewed articles ranging from 1991 to 2014 using the keywords cognitive rehabilitation, acquired brain injury, spinal cord injury, acute, and skill training. Searched databases included EBSCOhost, ProQuest, PsychINFO, PsychArticles, ScienceDirect, and PubMed. Initial searches revealed 71 possibly applicable articles. Exclusion criteria included those that were not published within the time range, case studies, and/or that were not peer-reviewed. Data Synthesis: The literature review demonstrated associations between the ease of applicability and efficacy of CR programs of functional outcomes for individuals with TBI and SCI. Individuals with SCI and TBI have greater impairments in processing speed, verbal learning, and motor speed that can complicate their functional capacity . Much of the literature indicates that CR could improve performance of cognitive abilities. Conclusion: There is some evidence of improved functional outcomes after an acquired injury. However, randomly controlled trials are needed to further assess the efficacy of rehabilitation programs concurrent with skill-based therapy. The authors conclude that acute care can assist with regaining social/functional abilities and improve emotional wellbeing to ensure long-term progress.