Objective: To determine whether HIV associated deficits in prospective memory (PM) are differentially affected by cue and delay interval across the lifespan. Method: The sample consisted of 125 Younger (48 with HIV) and 189 Older (112 with HIV) adults. As a part of a comprehensive research neuropsychological assessment, participants were administered the Memory for Intentions Screening Test (MIST), which includes 8 PM items that use either event-based or time-based cues across both 2-min and 15-min delay intervals. Results: The MANOVA analyses with age and HIV as between-subject variables and PM measures as within subjects factors yielded significant main effects of age and HIV; and significant interactions between age and PM, and between HIV and PM (ps < .05). Event-based PM impairment in 2-min delay was apparent in older groups, regardless of HIV serostatus. 15-min delay deteriorated event-based PM of the Older HIV+ group more than other groups. Time-based PM impairment in 2-min delay condition was observed in the Older HIV+ group. 15-min delay impaired PM of the groups but the effect was stronger for the older groups, regardless of HIV serostatus (ps < .05); however, further analysis revealed that Older HIV+ persons with neurocognitive disorders performed particularly poorly across the 15-min delay interval. Conclusion: Findings indicate that both aging and HIV disease affect PM performance. Among the older participants, the adverse influence of extended delays between encoding and retrieval was particularly pronounced for individuals with HIV associated neurocognitive disorders. Therefore, older persons with HIV-associated neurocognitive disorders may be more vulnerable to everyday failures in PM, including medication non-adherence.