Objective: The population-based Cardiovascular Risk Factors, Aging and Dementia (CAIDE) study developed a scoring system based upon demographic/medical information to assess the risk of adults developing dementia in late-life. However, its role in predicting progression from mild cognitive impairment (MCI) to dementia is unknown. We examined the baseline CAIDE risk score's predictive value in MCI progression to dementia. Method: Data collected from the National Alzheimer's Coordination Center Uniform Data Set included 1,778 participants (51% male; Mage = 74.07 ± 9.07) diagnosed with MCI at baseline visit, who had 3 subsequent annual visits. For this study, 252 (14.2%) participants progressed to dementia and 596 (33.5%) remained stable as MCI at 1-year, with sustained diagnoses at 2- and 3-year follow-up. CAIDE score was calculated by summing the weighted scores for age, education level, gender, systolic blood pressure, BMI, and total cholesterol at baseline visit per participant. Stepwise logistic regression model was used to determine the predictive value of CAIDE score in MCI progression, with APOE4 status (zero vs. ≥1 copies) as a covariate, using stable MCI for comparison. Results: T-test results revealed small but significantly different CAIDE scores between MCI progression (mean = 6.94 ± 2.04) and stable (mean = 7.28 ± 2.11; t(734) = 2.05, p < .05) groups. However, CAIDE scores did not significantly predict the MCI progression group (OR = 0.92; 95% CI = 0.84–1.00), with APOE4 as a covariate. Results remained non-significant with APOE4 excluded from the model (OR = 0.92; 95% CI = 0.86-1.00). Conclusion: In this retrospective study, CAIDE risk score did not predict MCI progression (compared to stable MCI) and should not be used as a marker for dementia at 3-years in this population.