Objective: The purpose of this study was to examine the impact of adverse prenatal and perinatal factors on symptom expression of children diagnosed with Chiari Malformation (CM). Method: As part of a larger study examining the developmental, academic, and social impact of CM, parental respondents (n = 96) of CM children completed a modified version of the Chiari-Symptom Profile (CSP) online. In addition, respondents identified the incidence of prenatal medications, pregnancy complications, distress during delivery, postnatal Apgar performance, and other neonatal medical complications (e.g., oxygen delivery, NICU admittance, feeding difficulties, and presence of jaundice). Results: Results indicated that reports of complications during pregnancy, child distress during labor, and administration of oxygen after birth were significantly associated with symptom severity ratings on the largest number of CSP items. Subsequently, multiple regression analyses were used to determine the variance accounted for on CSP items by these three predictors collectively. This model accounted for a significant amount of variance in 45% of CSP items, with the predicted symptom clusters reflecting sensory disturbances (numbness, pain, visual), general somatic complaints (sleep issues, dizziness/balance issues, fatigue), and emotional complaints. Conclusion: Although preliminary, results suggest that CM-diagnosed children experiencing three specific pre/perinatal factors (i.e., pregnancy complications + labor/delivery distress + oxygen) may be at a higher risk for later symptom expression (sensory, somatic, emotional) than those whose mothers do not report adverse pre/perinatal events. These findings may have implications in early identification and treatment of this population and should be the focus of future studies.