Objective: Previous research has yet to clearly define how underlying frontal and temporal memory systems are impacted by seizure foci in pediatric epilepsy. Therefore, we tested the relationship between CVLT-C interference variables (e.g., proactive, retroactive, and rapid forgetting) (Donders, 2006) and seizure focus (i.e., temporal (TLE) vs. frontal (FLE)). Primary hypotheses: TLE group will have greater retroactive interference effects than the FLE group and the FLE group will have larger proactive interference effects than the TLE group. 2. Method: Forty-one children (29 males and 12 females) treated for epilepsy at a regional children's medical center completed the CVLT-C. Epileptic focus and lateralization were classified for each child based on EEG, semiology, and neurologist diagnosis; resulting in TLE (n = 21) and FLE (n = 20) groups. Cases with multiple epilepsy foci were not included. There were significantly more males than females in the entire sample (p < .01) but there were no significant difference between groups. 3. Results: Significant differences were found in retroactive interference (p < .02) implicating the TLE group (TLE, Z = −.43; FLE, Z = +.40); non-significant findings for proactive interference (p = .39) with mean differences trending towards higher proactive interference in the FLE group (TLE, Z = .00; FLE, Z = −.15). Rapid forgetting statistically differed (p = .04), showing less rapid forgetting for the TLE group (TLE, Z = .83; FLE, Z = .43). Despite no differences in intrusions errors between classification groups (p = .28), intrusion errors differed significantly between left and right hemispheric focus (p < .01) with more intrusion errors recorded in left sided seizure foci (Right, Z = +.07; Left, Z = −.53). 4. Conclusion: Results highlight the interplay between frontal and temporal memory systems and how seizure foci differentially impact these processes in meaningful ways.
Memory Interference Effects on the California Verbal Learning Test (CVLT-C) Differ Based on Seizure Foci in Children
W Schraegle, N Nussbaum, A Stefanatos; B-72
Memory Interference Effects on the California Verbal Learning Test (CVLT-C) Differ Based on Seizure Foci in Children. Arch Clin Neuropsychol 2015; 30 (6): 549. doi: 10.1093/arclin/acv047.167
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