Objective: Previous research has yet to clearly define how underlying frontal and temporal memory systems are impacted by seizure foci in pediatric epilepsy. Therefore, we tested the relationship between CVLT-C interference variables (e.g., proactive, retroactive, and rapid forgetting) (Donders, 2006) and seizure focus (i.e., temporal (TLE) vs. frontal (FLE)). Primary hypotheses: TLE group will have greater retroactive interference effects than the FLE group and the FLE group will have larger proactive interference effects than the TLE group. 2. Method: Forty-one children (29 males and 12 females) treated for epilepsy at a regional children's medical center completed the CVLT-C. Epileptic focus and lateralization were classified for each child based on EEG, semiology, and neurologist diagnosis; resulting in TLE (n = 21) and FLE (n = 20) groups. Cases with multiple epilepsy foci were not included. There were significantly more males than females in the entire sample (p < .01) but there were no significant difference between groups. 3. Results: Significant differences were found in retroactive interference (p < .02) implicating the TLE group (TLE, Z = −.43; FLE, Z = +.40); non-significant findings for proactive interference (p = .39) with mean differences trending towards higher proactive interference in the FLE group (TLE, Z = .00; FLE, Z = −.15). Rapid forgetting statistically differed (p = .04), showing less rapid forgetting for the TLE group (TLE, Z = .83; FLE, Z = .43). Despite no differences in intrusions errors between classification groups (p = .28), intrusion errors differed significantly between left and right hemispheric focus (p < .01) with more intrusion errors recorded in left sided seizure foci (Right, Z = +.07; Left, Z = −.53). 4. Conclusion: Results highlight the interplay between frontal and temporal memory systems and how seizure foci differentially impact these processes in meaningful ways.