Objective: The brain processes underlying autistic disorder are still poorly understood. This literature review aims to examine the neural basis of auditory change-detection in this patient group by summarizing and interpreting recent studies that have investigated sound, and especially language processing of people with autism spectrum disorder (ASD) using brain's automatic change detection response mismatch negativity (MMN). Data Selection: A search was conducted within COBIMET virtual library, containing 74 databases, from 2000 to March 30th 2015, with key words “Autism and MMN.” It generated 1,766 articles, 23 were selected for review based on relevance. Data Synthesis: When non-speech sounds were used the results of most studies were somewhat contradictory. Either no significant differences were reported between autistic and control subjects in MMN amplitude, or MMN amplitudes were reduced in autistic children. Yet, some studies have reported shorter latencies when non-speech sounds were employed. Interestingly, most studies reported that the size of the MMN was typically diminished in autistic people when speech sounds were used. The same results were obtained from adults as well as children with autistic disorder. Also, both people with mild and severe autism showed diminished ability to discriminate speech sounds. Conclusion: Most studies reported that the speech-sound processing of the autistic people seem to be different from that of the controls confirming atypical change processing in autistic people. The shorter MMN latency when non-speech sounds were employed can be seen as an indicator of a greater tendency to switch attention to deviant events in autistic people as compared to the healthy controls.
Atypical Change Processing in Autistic People as Reflected by the Mismatch Negativity (MMN)
M Furtado, L George, M Cheour; B-90
Atypical Change Processing in Autistic People as Reflected by the Mismatch Negativity (MMN). Arch Clin Neuropsychol 2015; 30 (6): 555. doi: 10.1093/arclin/acv047.185
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